This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

EDWIN J. LEVY, M.D.; DONALD SCHETMAN, M.D.

Arch Dermatol. 1961;84(3):429-433.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Cyclic neutropenia is an unusual disease with numerous dermatologic manifestations. It was first reported in 1910 by Leale,¹ and Löblowitz,² who described the characteristic cyclic recurrence of oral ulcerations. They also noted the presence of an abnormal white blood cell count in their patients, but did not correlate this finding with the occurrence of mouth lesions. Thereafter there were numerous published reports of periodic oral ulcerations; however, the synchronous recurrence of neutropenia again was not investigated. It was not until 1930 that a definite association was established³ between the neutropenia and the mouth ulcerations, both of which recur along with fever, malaise, arthralgia, etc. at regular intervals of 21 days. There have been 32 additional case reports of cyclic neutropenia, with the majority appearing after 1946.

Despite the extensive ulcerations of the lips, tongue, palate, gums, and buccal mucosa, as well as other cutaneous manifestations, dermatologists generally . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

From the Department of Dermatology, School of Medicine, University of Pennsylvania.

Footnotes
Submitted for publication April 3, 1961.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?