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An Endocrinological Study

LEOPOLDO F. MONTES, M.D.; RICHARD M. CAPLAN, M.D.; GARDNER M. RILEY, Ph.D.; ARTHUR C. CURTIS, M.D.

Arch Dermatol. 1961;84(3):452-458.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Recent studies of patients with Fox-Fordyce disease^1-5 have demonstrated a paraductal apocrine sweat retention vesicle in the epidermis of involved areas. The disturbance may therefore be considered an ``apocrine miliaria''¹ in which the pruritus is caused by extravasated apocrine sweat produced upon stimulation of the large sweat glands. However, there has been no satisfactory explanation offered for (a) the abnormal accumulation of keratin at the follicular orifices, (b) the predilection for this condition to occur in women within the years of active reproductive life, (c) the reported tendency for improvement during pregnancy,^6,7 or (d) for the premenstrual or menstrual exacerbation of pruritus in many patients.^8-20

Concurring with Shelley and Levy's suggestion¹ that an endocrinological approach to the study of this disorder might be the most rewarding, we have attempted to clarify some of the above observations through a series of hormonal studies performed in the . . . [Full Text PDF of this Article]

Author Affiliations
BUENOS AIRES, ARGENTINA; ANN ARBOR, MICH.

From the Departments of Dermatology and Obstetrics and Gynecology, The University of Michigan Medical School.

Footnotes
Submitted for publication March, 13, 1961.

Supported in part by the Babcock Urological Endowment Fund (Dermatology) and by a grant from the University of Michigan Cancer Research Institute.

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