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I. Urocanic Acid

MARK ALLEN EVERETT, M.D.; J. H. ANGLIN, JR., M.S.; ARLEY T. BEVER, Ph.D.

Arch Dermatol. 1961;84(5):717-719.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Urocanic acid is one of the compounds which undergoes structural alteration upon exposure of the skin to ultraviolet light. It is the purpose of this paper to characterize these changes and comment upon their significance.

At the Third International Congress of Biochemistry at Brussels in 1955, a group of Czechoslovakian investigators demonstrated prevalence of urocanic (imidazolearylic) acid in human sweat in contrast to other body fluids and speculated that this compound might play a role in the protection against 300 mµ radiation.¹ They found that the concentration of urocanic acid in normal skins averaged 40-110 per ml.² and that a significant amount of exhibited 300 mµ irradiation was absorbed by it.³ In 1957 Tabachnick showed that urocanic acid was the major ultraviolet light absorber in white guinea pig skin, constituting 0.7% of total dry weight of epidermis.⁴ We have shown⁵ the erythema protection conferred by . . . [Full Text PDF of this Article]

Author Affiliations
OKLAHOMA CITY

From the Biochemical Laboratories, Department of Dermatology, University of Oklahoma School of Medicine. This Research supported by NIH Grant A-2344-R2.

Footnotes
Submitted for publication June 26, 1961.

Read at the Section on Dermatology, A.M.A. Annual Meeting, June, 1961.

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