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Special Reference to the Microscopic Alterations in the Cutaneous Hamartomas

WALTER R. NICKEL, M.D.; WILLIAM B. REED, M.D.

Arch Dermatol. 1962;85(2):209-226.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Tuberous sclerosis is a disease entity with protean manifestations, reported as being present in every organ and almost every structure of the body. It is familial and hereditary.

The skin lesions are not primarily problems of skin therapy. Gratification must be derived from making a diagnosis in the incomplete or forme fruste case in practice, without the classical triad of mental deficiency, epilepsy, and adenoma sebaceum. It is this type of case in which recommendations regarding marriage and reproduction are especially important in a condition unfamiliar to most physicians.

Historically the names of von Recklinghausen,¹ who first described brain and heart lesions; Bourneville,² who elaborated the brain findings; Pringle,³ whose name is attached to the facial lesions; Hallopeau-Leredde,⁴ who first described shagreen patches on the back; Sherlock,⁵ who coined the term ``epiloia,'' and Van der Hoeve,⁶ who first described the eye findings are all . . . [Full Text PDF of this Article]

Author Affiliations
SAN DIEGO, CALIF.; BURBANK, CALIF.

An uncommitted financial grant was given by Dr. Carl Herzog of Duke Laboratories to assist in defraying the expense involved in this study.

Footnotes
Submitted for publication Aug. 21, 1961.

Read before the 81st Annual Meeting of the American Dermatological Association, Inc., Tucker's Town, Bermuda, June 20, 1961.

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