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Clinical and Investigative Studies on 146 Patients

LEON GOLDMAN, M.D.; WILLIAM COHEN, M.D.

Arch Dermatol. 1962;85(2):266-269.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In a study of 19 patients, Fleischmajer¹ has shown that inunction with 2.5% hydrocortisone acetate given twice a day over prolonged periods produced no major systemic effects. Dermatologists are familiar also with the experiments on the systemic effect of percutaneous absorption of locally applied corticosteroids. These studies have been done by Danto and Maddin²; Smith³; Fitzpatrick, Griswold, and Hicks⁴; Gemzell, Haard and Nilzen⁵; Livingood, Hildebrand, Key, and Smith⁶; Witten, Shapiro and Silber⁷; Tschan and Adoni,⁸ and others.

For a long time we have been interested in topical corticosteroid therapy used over large and even uninvolved areas as a form of more effective therapy. The difficulties have been the expense of such therapy and the need for controlled clinical studies and for controlled assay studies of the systemic effects. We have used this technique in the study of topical hydrocortisone, prednisone, and dexamethasone. . . . [Full Text PDF of this Article]

Author Affiliations
CINCINNATI

From the Department of Dermatology of The College of Medicine of The University of Cincinnati.

Footnotes
Submitted for publication Aug. 4, 1961.

Flurandrenolone supplied as Cordran and Cordran-N by Dr. A. S. Ridolfo, Lilly Laboratory for Clinical Research, Eli Lilly Co., Indianapolis.

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