This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (12)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

MICHAEL M. SCHREIBER, M.D.; LIONEL Z. NAYLOR, B.S.

Arch Dermatol. 1962;86(1):58-62.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The observation of a patient with antihistamine photodermatitis due to diphenhydramine (Benadryl) and carbinoxamine, d-form (Twiston-RA) is of particular import due to the frequent use of antihistamines by physicians and their incorporation in proprietary "cold remedies."

Till now, reports of photosensitization to antihistamines have been limited to the phenothiazine derivatives, chlorpromazine¹ and promethazine (Phenergan).² This study, of a patient and her twin sister with antihistaminic photosensitivity, showed both phototoxic and photoallergic reactions to various antihistamines on photopatch testing. Structural formulas and ultraviolet light absorption peaks of the tested antihistamines were compared, and biopsies of the skin test sites were stained and studied in regard to mast cells.

Testing Procedure

The method of Curwen and Jillson³ was followed by us in photopatch testing. A Bausch and Lomb carbon arc (Therapeutic Sunshine C) lamp was used, which gave a constant output of light (2,500-7,000 A.), about 12 times the . . . [Full Text PDF of this Article]

Author Affiliations
NEW ORLEANS

Charity Hospital of Louisiana at New Orleans, Tulane School of Medicine, Department of Dermatology, Louisiana State University School of Medi-Student Research Assistant, Department of Dermatology (Dr. Schreiber); Junior Medical Student, cine (Mr. Naylor).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?