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Neomycin, Kanamycin, Streptomycin, and Bacitracin: An Experimental Study

STEPHAN EPSTEIN, M.D.; FREDERICK J. WENZEL, B.S.

Arch Dermatol. 1962;86(2):183-194.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Reports about cross-sensitivity among the various "Mycins" are contradictory. Sidi, Hincky, and Longueville^1,2 were the first to report cross-sensitivity between neomycin and streptomycin, and vice versa. Calnan and Sarkany³ were not able to confirm this fully, although 2 of their neomycin-sensitive patients also reacted to streptomycin. Pirilä and Wallenius⁴ and Pirilä and Rouhunkoski^5,6 as well as Hjorth⁷ reported that a great number of their neomycin-sensitive patients were also sensitive to bacitracin. This, however, is not the experience of others. To clarify these matters we investigated experimentally in guinea pigs sensitization to, and cross-sensitivity between, neomycin, kanamycin, streptomycin, and bacitracin.

Materials and Methods

We set out to sensitize albino guinea pigs, weighing between 400 and 500 gm., in groups of 10, to neomycin, kanamycin, streptomycin, dihydrostreptomycin, and bacitracin. The animals received 4 weekly injections of 5 mg. of the antibiotic mixed with Freund's adjuvant. This technique . . . [Full Text PDF of this Article]

Author Affiliations
MARSHFIELD, WIS.

From the Marshfield Clinic Foundation for Medical Research and Education (Dr. Epstein, Mr. Wenzel).

American Dermatological Association, Chandler, Ariz., March 28-31, 1962.

Footnotes
Presented at the 82d Annual Meeting of the

This study was supported by Grant No. E-3668 (R1) from the National Institute for Allergy and Infectious Diseases of the National Institutes of Health.

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