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A Simple and Rapid Method of Identifying Virus Particles

M. G. WILLIAMS; J. D. ALMEIDA; A. F. HOWATSON

Arch Dermatol. 1962;86(3):290-297.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

By means of the electron microscope, it is possible to identify visually many different viruses, and one might expect that this instrument would be useful as a clinical tool for aiding the diagnosis of virus diseases. So far, its use for this purpose has been very limited, mainly because of the difficulty of preparing specimens in a form suitable for examination in the electron microscope. In principle, the thin sectioning technique which has been so successfully applied in recent years to the study of minute biological structures can be used to detect and identify viruses in infected cells. In practice, however, the method is time consuming and presents technical difficulties that make it of little value to the clinician. Examination of virus-containing extracts after shadow casting with heavy metals has been suggested by Blank and Rake¹ as a means of diagnosis, and in fact, Nagler and Rake² used . . . [Full Text PDF of this Article]

Author Affiliations
TORONTO, CANADA

Department of Medical Biophysics, University of Toronto and Division of Biological Research, The Ontario Cancer Institute.

Footnotes
Financial support for this research was supplied by: The Foster Bequest Fund of the University of Toronto, The National Institutes of Health (U.S.) Grant No. C-4964(C2)V&R, and the National Cancer Institute of Canada.

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