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I. A Histologic Study of Serial Biopsy Specimens

PAUL M. CROSSLAND, M.D.

Arch Dermatol. 1962;86(6):745-752.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Improvements in radiotherapy of skin cancer can be achieved through fuller knowledge of the biologic effects of radiation. This preliminary study attempts to reach a better understanding of the basic effects by a careful analysis of histopathologic changes following conventional superficial roentgen irradiation of 3 lesions of basal cell carcinoma. The changes were observed in multiple specimens from each tumor removed by biopsy at intervals during and after the periods of therapy.

Material and Methods

Biopsy specimens of each tumor were taken before x-ray therapy was instituted, before each treatment was given, and at intervals after completion of each course of treatment.

Tumors 1 and 2 were in the same patient, a 74-year-old man. Tumor 1, which he asserted had been present only 6 months, was an ulcerated tumor of the helix and posterior surface of the left ear, measuring 3 cm. in diameter. Four millimeter punch biopsy specimens were . . . [Full Text PDF of this Article]

Author Affiliations
SANTA ROSA, CALIF.

A Clinical Associate Professor of Dermatology, Stanford University School of Medicine.

From the Department of Dermatology, Stanford University School of Medicine.

Footnotes
Read before the 82d Annual Meeting of the American Dermatological Association, Chandler, Ariz., March 27-31, 1962.

This study was supported by the American Cancer Society's Institutional Research Grant No. 70-4619-22, obtained through Stanford University School of Medicine.

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