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A Follow-Up Study

MEYER L. NIEDELMAN, M.D.; VICTOR A. McKUSICK, M.D.

Arch Dermatol. 1962;86(6):779-782.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1947 Niedelman¹ described an Italian-American family in which acrokeratosis verruciformis (Hopf) occurred in 14 members in 4 generations. The inheritance followed a dominant pattern. Van den Bosch² has recently suggested that the condition is an X-linked dominant rather than an autosomal dominant. The suggestion was based on the facts that females are about twice as frequently affected as males and that no certain instance of male-to-male transmission has been reported. Assuming complete penetrance, the condition if X-linked, should, furthermore, affect all daughters of an affected male. Van den Bosch was prompted to analyze the reported pedigrees by his own observations³ of a complex, apparently X-linked trait in which acrokeratosis verruciformis is one component.

Follow-up of the family reported in 1947 seemed indicated, in order to corroborate the . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA; BALTIMORE

Professor of Dermatology, Temple University School of Medicine (Dr. Niedelman); Professor of Medicine, Division of Medical Genetics, Department of Medicine, Johns Hopkins University School of Medicine (Dr. McKusick).

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