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Disseminated Type With Ulceronodular Dermatitis and Leukopenia: Report of Two Cases

GEORGE W. BINKLEY, MD

Arch Dermatol. 1963;88(5):637-643.

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Pathergy has been defined as the totality of the morbid phenomena which can be produced by a state of altered reactivity.

The related chronic necrotizing diseases of single or multiple organs have posed many problems. Of these problems, the most difficult are the nomenclature, the causation, and the therapy. The variations in the patterns of pathergic granulomatosis are legion. One of the earliest of these illnesses to be described was lethal midline granulomatosis.¹ Soon after came dermatitis nodularis necrotica.^2-4 Dermatitis nodularis necrotica presents distinctive clinical features which, at first, forced one to regard it as unrelated to midline granuloma and other chronic dermonecrotic diseases; now I consider it a pathergic disease. Polyarteritis nodosa⁵ belongs here, as does Wegener's granulomatosis⁶ (pathergic granulomatosis⁷) with all its designations and eponyms. Laymon⁸ brought malignant papulosis with atrophy into this group. Winkelmann⁹ and others¹⁰ have reviewed the . . . [Full Text PDF of this Article]

Author Affiliations
CLEVELAND

Assistant Clinical Professor of Medicine (Dermatology), Western Reserve University.

Footnotes
Presented at the 83rd Annual Meeting of the American Dermatological Association, Inc., April 16-19, 1963.

Supported in part by grants from the Department of Health, Education and Welfare and Armed Forces Epidemiology Board.

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