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JOSEPH V. KLAUDER, M.D.

Arch Derm Syphilol. 1924;9(4):446-458.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In the chemotherapy of trypanosomiasis of man and animals, it is possible to produce arsenic-fast strains of various trypanosomes after these organisms have been subjected a few times to the action of certain arsenic compounds short of the sterilizing dose. Experiments of this nature have been conducted with atoxyl, arsacetin and other arsenic compounds. If the organisms are not all destroyed after the initial injection, the offspring of the remaining ones are more resistant to the action of the drug than the preceding generation. A larger dose of the arsenical compound is required to destroy the organism and to overcome this increased resistance. This increased resistance may be developed to such an extent that the amount of the arsenic compound required to exert a parasitotropic action is in excess of its organotropic action. Indeed, the production of drug-fast strains of various trypanosomes is an admitted failure of chemotherapy of trypanosomiasis . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

Philadelphia. t the From the Research Institute of Cutaneous Medicine, Philadelphia.

Footnotes
Read as part of the paper "Studies in Experimental Syphilis". Forth-Sixth Annual Meeting of the American Dermatological Association, Ann Arbor, Mich., June 7-9, 1923.

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