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Effects of Demethylchlortetracycline Therapy

FRANK E. CORMIA, MD

Arch Dermatol. 1964;90(6):624-625.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

It is well known that hyperpigmentation may develop in darker-skinned races after even small doses of x-radiation. The skin of lightly pigmented Negroes may become nearly black after a few weekly doses of 75 roentgens (r) of superficial x-ray therapy. This effect occurs without visible inflammatory change. During the past few years, attention has been called to photosensitivity, or more properly, phototoxic cutaneous reactions in patients exposed to sunlight during demethylchlortetracycline administration.^1,2 The effect has been shown to be a quantitative one,³ ie, developing mainly when a minimum of 600 mg of this drug was given daily. It was further shown by Schorr and Monash⁴ to be potentiated by both ultraviolet rays of wavelength between 2,800 Angstroms (A) and 3,200 A, and by rays with longer wavelength than 3,150 A which pass through common window glass.

Report of Case

Recently, I observed the development of moderately severe . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From The New York Hospital and Cornell University Medical College.

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