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Thomas K. Burnham, MB, BS; Thomas R. Neblett, PhD; Gerald Fine, MD
Henry Ford Hospital Detroit

Arch Dermatol. 1968;97(1):99-100.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Drs. Rowell and Beck in their article in the September 1967 issue of the ARCHIVES¹ once again stated that the speckle-inducing antinuclear antibody is as frequent in systemic lupus erythematosus (SLE) as it is in scleroderma. We originally reported that "speckled" fluorescence was almost exclusively confined to scleroderma in our series^2,3 even at the titration endpoint. We suggested that this difference might be attributable to Drs. Rowell and Beck including "speckle-like threads"^2-4 which do occur with equal frequency in SLE and scleroderma, with true "speckles" in their classification of "speckled" fluorescence. Interestingly enough, in a letter to the editor of the Lancet by Drs. Beck and Hughes⁵ Fig C, depicting "speckled" fluorescence produced by the diluted serum of an SLE patient, appeared in fact to illustrate "speckle-like thready" fluorescence.

Since our original reports, we have now tested 5,723 patients and have established that true . . . [Full Text PDF of this Article]

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