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With Particular Reference to Mycosis Fungoides and Exfoliative Erythroderma

Stanley M. Bierman, MD

Arch Dermatol. 1968;97(6):699-711.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

AUNITARIAN theory of the pathogenesis of malignant lymphoma seems improbable considering the multiplicity of morphologic types, histopathologic distinctions and variable clinical courses suggesting that there are multiple etiologic determinants of lymphoid malignancies. The induction of lymphoma in mice by oncogenic viruses^1-4 and chemical carcinogens,^5-8 epidemiologic⁹ and hereditary influences^10-12 in Hodgkin's disease, the development of lymphomas as a consequence of the administration of anticonvulsant drugs¹³ and exposure to x-radiation,^14,15 and studies of Burkitt's lymphoma¹⁶ all bespeak a great diversity of inductive influences. During the past decade persuasive insight into the pathogenesis of lymphoid malignancies has been advanced by the revelation that immunologic aberrations predispose to, are inductive, or are important associated features of malignant lymphoproliferative disease. The purpose of this paper is to review the experimental studies and clinical research relevant to the determinant role of abnormalities of immune mechanisms in the pathogenesis . . . [Full Text PDF of this Article]

Author Affiliations
Los Angeles

From the Department of Medicine, Division of Dermatology, University of California, Los Angeles Medical Center and the divisions of dermatology, Wadsworth General and Long Beach Veterans hospitals.

Footnotes
Accepted for publication Jan 8, 1968.

Reprint requests to 1100 Glendon Ave, Los Angeles, 90024 (Dr. Bierman).

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